5 Easy Facts About Dup 747 Described

cyclosporine will increase the stage or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

Procedure will cause peripheral neuropathy (predominantly sensory); nonetheless, instances of intense sensory and motor peripheral neuropathy are already reported

nelfinavir will enhance the level or outcome of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

Monitor Closely (1)triclabendazole will increase the stage or outcome of bortezomib by impacting hepatic enzyme CYP2C19 metabolism.

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The therapeutic dose of bortezomib is individualized in Every single patient to avoid overdose. Lethal results occurred in humans pursuing the administration of a lot more than 2 times the suggested therapeutic dose of bortezomib. The signs or symptoms from overdose integrated the acute onset of symptomatic hypotension and thrombocytopenia. As there isn't a identified antidote for bortezomib overdosage, monitoring of crucial symptoms and appropriate supportive care should be initiated when drug overdosage is suspected.

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tecovirimat will raise the degree or influence of bortezomib by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Monitor for adverse consequences if coadministered with delicate substrates of these enzymes.

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topiramate will decrease the extent or result of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known. Caution is encouraged with concurrent use.

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verapamil will boost the degree or result of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

crizotinib will increase amounts of bortezomib by CP-866087 affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction can be necessary for coadministered drugs which have been predominantly metabolized by CYP3A.